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Pycardtm1Vmd
Targeted Allele Detail
Nomenclature
Symbol: Pycardtm1Vmd
Name: PYD and CARD domain containing; targeted mutation 1, Vishva M Dixit
MGI ID: MGI:3046932
Synonyms: Asc-, ASC-
Gene: Pycard  Location: Chr7:127991373-127993867 bp, - strand  Genetic Position: Chr7, 69.88 cM, cytoband F4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91292
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced the entire coding sequence. Southern blot confirmed recombination and Western blot demonstrated lack of transcript in mutant macrophages. (J:91292)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pycard Mutation:  5 strains or lines available
References
Original:  J:91292 Mariathasan S, et al., Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature. 2004 Jul 8;430(6996):213-8
All:  184 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory