Pycard^tm1Vmd
Targeted Allele Detail

Summary

• Symbol: Pycard^tm1Vmd
• Name: PYD and CARD domain containing; targeted mutation 1, Vishva M Dixit
• MGI ID: MGI:3046932
• Synonyms: Asc^-, ASC^-
• Gene: Pycard Location: Chr7:127590545-127593039 bp, - strand Genetic Position: Chr7, 69.88 cM, cytoband F4
• Alliance: Pycard^tm1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91292
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced the entire coding sequence. Southern blot confirmed recombination and Western blot demonstrated lack of transcript in mutant macrophages. (J:91292)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pycard Mutation: 13 strains or lines available

References

• Original: J:91292 Mariathasan S, et al., Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature. 2004 Jul 8;430(6996):213-8
• All: 230 reference(s)