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Targeted Allele Detail
Symbol: Mmp14tm1Noda
Name: matrix metallopeptidase 14 (membrane-inserted); targeted mutation 1, Makoto Noda
MGI ID: MGI:3046860
Synonyms: MT1-MMP-, MT1-MMP KO
Gene: Mmp14  Location: Chr14:54431612-54441265 bp, + strand  Genetic Position: Chr14, 27.79 cM
Germline Transmission:  Earliest citation of germline transmission: J:91198
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe allele was created with a targeting vector replacing and disrupting exons 1-5, which encode the catlytic domain, with a gene encoding LacZ fused to a nuclear localizing signal. The PGK-gpt/neomycin-resistance gene cassette was inserted in the reverse direction, downstrem of lacZ. Northern blot analysis of homozygous mutant fibroblasts show no detectable mRNA and absence of protein was demonstrated in Western blot of mutant embryos. (J:91198, J:158339)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mmp14 Mutation:  24 strains or lines available
Original:  J:91198 Oh J, et al., Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice. Oncogene. 2004 Jun 24;23(29):5041-8
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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