About   Help   FAQ
Otx2tm6Sia
Targeted Allele Detail
Nomenclature
Symbol: Otx2tm6Sia
Name: orthodenticle homolog 2; targeted mutation 6, Shinichi Aizawa
MGI ID: MGI:3046840
Synonyms: Otx2deltaFM2
Gene: Otx2  Location: Chr14:48657679-48667644 bp, - strand  Genetic Position: Chr14, 25.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91011
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe FM2 enhancer region (1.0 kb) was replaced with a floxed neomycin-resistance gene. Southern blot and PCR confirmed recombination. (J:91011)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:  37 strains or lines available
References
Original:  J:91011 Kurokawa D, et al., Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development. 2004 Jul;131(14):3319-31
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/24/2015
MGI 5.21
The Jackson Laboratory