Prkcd^tm1Msg
Targeted Allele Detail

Summary

• Symbol: Prkcd^tm1Msg
• Name: protein kinase C, delta; targeted mutation 1, Robert O Messing
• MGI ID: MGI:3046799
• Synonyms: PKC delta^-, PKCdelta^-
• Gene: Prkcd Location: Chr14:30317311-30348167 bp, - strand Genetic Position: Chr14, 18.82 cM
• Alliance: Prkcd^tm1Msg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91377
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 was floxed and removed via transient cre-mediated recombination. Exon 2 contains the translation start codon. Northern blot showed absence of transcript in mutants and Western blot confirmed absence of protein in mutants. (J:91377)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkcd Mutation: 52 strains or lines available

References

• Original: J:91377 Chou WH, et al., Neutrophil protein kinase Cdelta as a mediator of stroke-reperfusion injury. J Clin Invest. 2004 Jul;114(1):49-56
• All: 10 reference(s)