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Fn1tm2Bwg
Targeted Allele Detail
Summary
Symbol: Fn1tm2Bwg
Name: fibronectin 1; targeted mutation 2, Brigham and Women's Hospital
MGI ID: MGI:3046766
Synonyms: EIIIAflox
Gene: Fn1  Location: Chr1:71624679-71692359 bp, - strand  Genetic Position: Chr1, 36.05 cM, cytoband C1-C5
Alliance: Fn1tm2Bwg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90917
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe EIIIA domain encoding exon was floxed following transient cre-mediated excision of an upstream floxed neo. Southern blot confirmed recombination. (J:90917)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fn1 Mutation:  129 strains or lines available
References
Original:  J:90917 Tan MH, et al., Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosis. Blood. 2004 Jul 1;104(1):11-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory