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Ctswtm1Ctnp
Targeted Allele Detail
Nomenclature
Symbol: Ctswtm1Ctnp
Name: cathepsin W; targeted mutation 1, Christine T N Pham
MGI ID: MGI:3046638
Synonyms: CtsW-
Gene: Ctsw  Location: Chr19:5465240-5468498 bp, - strand  Genetic Position: Chr19, 4.33 cM, cytoband A
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91265
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 through intron 2 were replaced with a loxP flanked neo cassette via homologous recombination. S1 nuclease protection and western blot analysis confirmed the absence of mRNA and protein in activated lymphocytes from homozygous null mice. (J:91265)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctsw Mutation:  9 strains or lines available
References
Original:  J:91265 Ondr JK, et al., Characterization of murine cathepsin W and its role in cell-mediated cytotoxicity. J Biol Chem. 2004 Jun 25;279(26):27525-33
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory