Hes7^tm2Kag
Targeted Allele Detail

Summary

• Symbol: Hes7^tm2Kag
• Name: hes family bHLH transcription factor 7; targeted mutation 2, Ryoichiro Kageyama
• MGI ID: MGI:3046536
• Synonyms: Hes7^118G, Hes7^tm2Rka
• Gene: Hes7 Location: Chr11:69011230-69014881 bp, + strand Genetic Position: Chr11, 42.38 cM
• Alliance: Hes7^tm2Kag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91127
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: An A to G transition mutation was introduced at nucleotide residue 118 in exon 1 converting a lysine into an arginine (K14R). This mutation increased the half-life of the protein from about 22 minutes to about 30 minutes without knocking out repressor activity. In situ analysis indicates that the mutant protein is expressed. (J:91127)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hes7 Mutation: 21 strains or lines available

References

• Original: J:91127 Hirata H, et al., Instability of Hes7 protein is crucial for the somite segmentation clock. Nat Genet. 2004 Jul;36(7):750-4
• All: 1 reference(s)