Ighatm1(Myc)Janz
Targeted Allele Detail
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Symbol: |
Ighatm1(Myc)Janz |
Name: |
immunoglobulin heavy constant alpha; targeted mutation 1, Siegfried Janz |
MGI ID: |
MGI:3046399 |
Synonyms: |
c-myc-KICalpha, IgH-MycCα, IgH-MycCalpha, iMycCalpha |
Gene: |
Igha Location: Chr12:113219824-113223856 bp, - strand Genetic Position: Chr12, 62.09 cM
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Allele Type: |
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Targeted (Inserted expressed sequence) |
Mutation: |
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Insertion
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Ighatm1(Myc)Janz expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Note |
Mouse |
Myc |
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Mutation details: A construct consisting of a 1.5 kb segment of genomic 5' flanking sequence from the mouse Myc gene with the P1/P2 promoters, the first noncoding exon, a mouse Myc intron-less cDNA clone with an in-frame 6x histidine tag sequence on the 3' end, a short segment of the 3' UTR including the major polyadenylation signal, and a loxP site flanked neomycin resistance gene cassette was inserted in opposite transcriptional orientation into intron 1 of the C alpha locus via homologous recombination. The neo cassette was subsequently removed by mating to cre transgenic mice.
(J:90901)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:90901 Cheung WC, et al., Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice. J Clin Invest. 2004 Jun;113(12):1763-73 |
All: |
12 reference(s) |
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