Igha^tm1(Myc)Janz
Targeted Allele Detail

Nomenclature

• Symbol: Igha^tm1(Myc)Janz
• Name: immunoglobulin heavy constant alpha; targeted mutation 1, Siegfried Janz
• MGI ID: MGI:3046399
• Synonyms: c-myc-KICalpha, IgH-MycC^α, IgH-MycC^alpha, iMyc^Calpha
• Gene: Igha Location: Chr12:113219824-113223856 bp, - strand Genetic Position: Chr12, 62.09 cM

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90901
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Igha^tm1(Myc)Janz expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Mouse	Myc

• Mutation details: A construct consisting of a 1.5 kb segment of genomic 5' flanking sequence from the mouse Myc gene with the P1/P2 promoters, the first noncoding exon, a mouse Myc intron-less cDNA clone with an in-frame 6x histidine tag sequence on the 3' end, a short segment of the 3' UTR including the major polyadenylation signal, and a loxP site flanked neomycin resistance gene cassette was inserted in opposite transcriptional orientation into intron 1 of the C alpha locus via homologous recombination. The neo cassette was subsequently removed by mating to cre transgenic mice. (J:90901)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igha Mutation: 9 strains or lines available

References

• Original: J:90901 Cheung WC, et al., Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice. J Clin Invest. 2004 Jun;113(12):1763-73
• All: 12 reference(s)