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Cdhr1tm1Nat
Targeted Allele Detail
Nomenclature
Symbol: Cdhr1tm1Nat
Name: cadherin-related family member 1; targeted mutation 1, Jeremy Nathans
MGI ID: MGI:3046299
Synonyms: prCAD-
Gene: Cdhr1  Location: Chr14:36799814-36820304 bp, - strand  Genetic Position: Chr14, 21.29 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73286
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced exons 10-17, which encode the C-terminal two thirds of the protein. Northern blot and immunohistochemical analysis confirmed the absence of encoded transcript and protein, respectively. (J:73286)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdhr1 Mutation:  32 strains or lines available
References
Original:  J:73286 Rattner A, et al., A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival. Neuron. 2001 Dec 6;32(5):775-86
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory