About   Help   FAQ
Pfat3C57BL/6J
QTL Variant Detail
Summary
QTL variant: Pfat3C57BL/6J
Name: predicted fat percentage 3; C57BL/6J
MGI ID: MGI:3046226
QTL: Pfat3  Location: Chr13:53101530-53101640 bp  Genetic Position: Chr13, cM position of peak correlated region/allele: 27.68 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:51538

Genome scan was performed on phenotypically extreme animals from a (C57BL/6J x DBA/2J)F2 population to identify QTLs associated with predicted percent body fat and fat pad percentage. Eighty evenly spaced microsatellite markers were screened. Several obesity candidate genes were also analyzed (agouti chr2, 92 cM; Lepr chr4, 47.5 cM; Lep chr6, 10.4 cM; Tub chr7, 49.5 cM; Cpe chr8, 15.9 cM).

Loci showing significant linkage to predicted fat percentage mapped to mouse Chromosomes 4 (Pfat1), 6 (Pfat2), 13 (Pfat3), and 15 (Pfat4). Pfat1 mapped to 30 cM on mouse Chromosome 4 with LOD=5 at D4Mit81. Pfat2 mapped to 38.1 cM on mouse Chromosome 6 with LOD=4.9 at D6Mit102. Pfat3 mapped to 20 cM on mouse Chromosome 13 with LOD=5.3 at D13Mit248. Pfat4 mapped to 43.3 cM on mouse Chromosome 15 with LOD=8.6 at D15Mit29.

A locus on mouse Chromosome 5 showed suggestive linkage to fatness at D5Mit227 (4 cM, LOD=3.1). The candidate genes did not show significant linkage to fatness. No linkage to fat pad percentage was detected.

References
Original:  J:51538 Keightley PD, et al., Test of candidate gene--quantitative trait locus association applied to fatness in mice. Heredity. 1998 Dec;81(Pt 6):630-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory