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Card11tm1Pngr
Targeted Allele Detail
Nomenclature
Symbol: Card11tm1Pngr
Name: caspase recruitment domain family, member 11; targeted mutation 1, Josef M Penninger
MGI ID: MGI:3045950
Synonyms: card11-, carma1 ko
Gene: Card11  Location: Chr5:140872990-141000582 bp, - strand  Genetic Position: Chr5, 79.42 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:84036
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4 and part of exon 5, including the start codon and the code for the CARD region, were replaced with a neo cassette. Western blot of splenocytes indicated absence of protein in mutant animals. (J:84036)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Card11 Mutation:  26 strains or lines available
References
Original:  J:84036 Hara H, et al., The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity. 2003 Jun;18(6):763-75
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory