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Targeted Allele Detail
Symbol: Nkx3-1tm1.1Saa
Name: NK3 homeobox 1; targeted mutation 1.1, Sarki A Abdulkadir
MGI ID: MGI:3045877
Synonyms: Nkx3.1-
Gene: Nkx3-1  Location: Chr14:69190638-69194662 bp, + strand  Genetic Position: Chr14, 36.02 cM
Germline Transmission:  Earliest citation of germline transmission: J:74350
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsAs a result of crossing Nkx3-1tm1Saa with transgenic mice expressing cre in the germ line, the floxed exon 2 and neo cassette were excised, leaving exon 1 and a single loxP site. RT-PCR analysis and immunohistochemical analyses confirmed loss of mRNA and protein expression in the posterior prostates of mutant mice. (J:74350)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx3-1 Mutation:  17 strains or lines available
Original:  J:74350 Abdulkadir SA, et al., Conditional loss of nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol Cell Biol. 2002 Mar;22(5):1495-503
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory