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MybPlt4
Chemically induced Allele Detail
Nomenclature
Symbol: MybPlt4
Name: myeloblastosis oncogene; Plt4
MGI ID: MGI:3045843
Synonyms: c-MybPlt4
Gene: Myb  Location: Chr10:21124935-21160984 bp, - strand  Genetic Position: Chr10, 9.75 cM
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsAs a result of an A to T transversion, this allele has an aspartic acid to valine mutation at residue 384 in the leucine-zipper domain. Northern blot indicates mRNA is expressed at normal levels in hematopoitic tissues but a transactivation assay revealed a significant reduction in protein activity as compared to wild-type. (J:89601)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myb Mutation:  12 strains or lines available
References
Original:  J:89601 Carpinelli MR, et al., Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6553-8
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory