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Ightm2Cog
Targeted Allele Detail
Summary
Symbol: Ightm2Cog
Name: immunoglobulin heavy chain complex; targeted mutation 2, Michel Cogne
MGI ID: MGI:3045811
Synonyms: Rr185tm2Cog
Gene: Igh  Location: Chr12:113222388-115973574 bp, - strand  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90548
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Modified regulatory region, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThis allele has a deletion of approximately 4.6 kb in the Imu-Cmu intron. Cre-mediated recombination removed a floxed neo inserted in the intron, leaving a loxp sequence. Homozygous mutants displayed a 5- to 20-fold decrease in surface expression of IgG1, IgG3 and IgA, and a 2- to 5- fold decrease in IgG2b and IgG2a as compared to wild-type. No alteration was found in IgM expression. (J:90548)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  43 strains or lines available
References
Original:  J:90548 Khamlichi AA, et al., Immunoglobulin class-switch recombination in mice devoid of any S mu tandem repeat. Blood. 2004 May 15;103(10):3828-36
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory