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Tgfbr2tm1Roes
Targeted Allele Detail
Nomenclature
Symbol: Tgfbr2tm1Roes
Name: transforming growth factor, beta receptor II; targeted mutation 1, Jurgen Roes
MGI ID: MGI:3045693
Synonyms: TbetaRIIfl, TbRIIfl, TGFbetaRIIlox
Gene: Tgfbr2  Location: Chr9:116087695-116175363 bp, - strand  Genetic Position: Chr9, 68.39 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90558
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neomycin resistance gene was introduced in intron 2 and a single loxP site about 1 kb downstream from exon 3 by homologous recombination; transient expression of Cre recombinase in ES cells excised the neo gene, leaving exon 3 flanked by single loxP sites. (J:90558)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tgfbr2 Mutation:  7 strains or lines available
References
Original:  J:90558 Cazac BB, et al., TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo. Immunity. 2000 Oct;13(4):443-51
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory