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Sstr2tm1Pce
Targeted Allele Detail
Nomenclature
Symbol: Sstr2tm1Pce
Name: somatostatin receptor 2; targeted mutation 1, Piers C Emson
MGI ID: MGI:3045430
Synonyms: sst2-KO, Sstr2lacZ
Gene: Sstr2  Location: Chr11:113619342-113626028 bp, + strand  Genetic Position: Chr11, 79.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:126001
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe first 654 bp of the single exon gene was replaced with a lacZ reporter and a neomycin resistance gene, with the initiation codon of lacZ inserted in frame with original the transcription start site. Southern blot confirmed recombination and reverse transcription PCR demonstrated absence of normal mRNA and presence of lacZ mRNA in mutants. (J:89708)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sstr2 Mutation:  18 strains or lines available
References
Original:  J:126001 Allen JP, et al., Identification of cells expressing somatostatin receptor 2 in the gastrointestinal tract of Sstr2 knockout/lacZ knockin mice. J Comp Neurol. 2002 Dec 16;454(3):329-40
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory