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Btlatm1Kay
Targeted Allele Detail
Nomenclature
Symbol: Btlatm1Kay
Name: B and T lymphocyte associated; targeted mutation 1, Jonathan Kaye
MGI ID: MGI:3045408
Synonyms: BTLA-
Gene: Btla  Location: Chr16:45224315-45252892 bp, + strand  Genetic Position: Chr16, 29.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89864
Parent Cell Line:  CMTI-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 2, which encodes the Ig-like domain, was disrupted by the insertion of a neo in reverse transcriptional orientation via homologous recombination. Southern blots confirmed gene targeting and RT-PCR indicated failure of mutant spleen cells to express full-length mRNA. (J:89864)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Btla Mutation:  12 strains or lines available
References
Original:  J:89864 Han P, et al., An inhibitory Ig superfamily protein expressed by lymphocytes and APCs is also an early marker of thymocyte positive selection. J Immunol. 2004 May 15;172(10):5931-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory