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Lrp1btm1Her
Targeted Allele Detail
Nomenclature
Symbol: Lrp1btm1Her
Name: low density lipoprotein-related protein 1B (deleted in tumors); targeted mutation 1, Joachim Herz
MGI ID: MGI:3045402
Synonyms: Lrp1b-
Gene: Lrp1b  Location: Chr2:40595248-42653598 bp, - strand  Genetic Position: Chr2, 24.51 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90197
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 88, which encodes the membrane-spanning segment, was replaced with a neo. Allele-specific PCR was used to detect the gene disruption and Western blot confirmed absence of the protein in mutant brains. (J:90197)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrp1b Mutation:  4 strains or lines available
References
Original:  J:90197 Marschang P, et al., Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Mol Cell Biol. 2004 May;24(9):3782-93
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory