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Targeted Allele Detail
Symbol: Lrp1btm1Her
Name: low density lipoprotein-related protein 1B (deleted in tumors); targeted mutation 1, Joachim Herz
MGI ID: MGI:3045402
Synonyms: Lrp1b-
Gene: Lrp1b  Location: Chr2:40595246-42653624 bp, - strand  Genetic Position: Chr2, 24.51 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:90197
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 88, which encodes the membrane-spanning segment, was replaced with a neo. Allele-specific PCR was used to detect the gene disruption and Western blot confirmed absence of the protein in mutant brains. (J:90197)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrp1b Mutation:  110 strains or lines available
Original:  J:90197 Marschang P, et al., Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Mol Cell Biol. 2004 May;24(9):3782-93
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory