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Abcc6tm1Jfk
Targeted Allele Detail
Nomenclature
Symbol: Abcc6tm1Jfk
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 6; targeted mutation 1 John F Klement
MGI ID: MGI:3045236
Synonyms: Abcc6-
Gene: Abcc6  Location: Chr7:45967555-46030302 bp, - strand  Genetic Position: Chr7, 29.64 cM, cytoband B3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101372
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced exons 15-18 of the locus. Transcript proved to be absent in Northern blot analysis. (J:101372)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abcc6 Mutation:  45 strains or lines available
References
Original:  J:101372 Klement JF, et al., Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues. Mol Cell Biol. 2005 Sep;25(18):8299-310
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory