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Targeted Allele Detail
Symbol: Map3k4tm1Flv
Name: mitogen-activated protein kinase kinase kinase 4; targeted mutation 1, Richard A Flavell
MGI ID: MGI:3044978
Synonyms: MEKK4-
Gene: Map3k4  Location: Chr17:12227621-12318796 bp, - strand  Genetic Position: Chr17, 8.42 cM
XY gonad in Map3k4tm1Flv/Map3k4tm1Flv embryos exhibits overt ovarian morphology

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:90112
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted 5' to exon 3 and a floxed neomycin resistance cassette was placed 3' to the exon. Chimeric male mice were bred to female mice carrying Tg(Tek-cre)12Flv to delete exon 3 and the neomycin resistance gene. This removes the entire GADD45-binding domain and causes a frame shift and premature termination. Absence of protein was confirmed by Western blot analysis. (J:90112)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 69 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Map3k4 Mutation:  45 strains or lines available
This allele was derived from Map3k4.
Original:  J:90112 Chi H, et al., GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. EMBO J. 2004 Apr 7;23(7):1576-86
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory