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Terttm1Leah
Targeted Allele Detail
Nomenclature
Symbol: Terttm1Leah
Name: telomerase reverse transcriptase; targeted mutation 1, Lea Harrington
MGI ID: MGI:3044918
Synonyms: mTert-, Tertdelta
Gene: Tert  Location: Chr13:73627001-73649041 bp, + strand  Genetic Position: Chr13, 40.12 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90866
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsFive exons were replaced with a neomycin selection cassette inserted by homologous recombination. The deletion was reported to disrupt the telomerase-specific motif as well as the first three of the seven reverse transcriptase motifs. Transcript was undetected in homozygous mutant ES cells and in testicular tissue from first generation homozygous mutant mice, as shown by RT-PCR analysis. No telomerase activity was detected in homozygous mutant ES cell clones and in tissue extracts from homozygous mutant testes, liver, thymus, lung and kidney, as determined by TRAP analysis. (J:90866)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tert Mutation:  4 strains or lines available
References
Original:  J:90866 Liu Y, et al., The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr Biol. 2000 Nov 16;10(22):1459-62
All:  13 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory