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Targeted Allele Detail
Symbol: Terttm1Leah
Name: telomerase reverse transcriptase; targeted mutation 1, Lea Harrington
MGI ID: MGI:3044918
Synonyms: mTert-, Tertdelta
Gene: Tert  Location: Chr13:73626911-73649843 bp, + strand  Genetic Position: Chr13, 40.12 cM
Germline Transmission:  Earliest citation of germline transmission: J:90866
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsFive exons were replaced with a neomycin selection cassette inserted by homologous recombination. The deletion was reported to disrupt the telomerase-specific motif as well as the first three of the seven reverse transcriptase motifs. Transcript was undetected in homozygous mutant ES cells and in testicular tissue from first generation homozygous mutant mice, as shown by RT-PCR analysis. No telomerase activity was detected in homozygous mutant ES cell clones and in tissue extracts from homozygous mutant testes, liver, thymus, lung and kidney, as determined by TRAP analysis. (J:90866)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tert Mutation:  35 strains or lines available
Original:  J:90866 Liu Y, et al., The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr Biol. 2000 Nov 16;10(22):1459-62
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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