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Cnot7tm1Tno
Targeted Allele Detail
Summary
Symbol: Cnot7tm1Tno
Name: CCR4-NOT transcription complex, subunit 7; targeted mutation 1, Tetsuo Noda
MGI ID: MGI:3044887
Synonyms: Cnot7-
Gene: Cnot7  Location: Chr8:40945581-40968888 bp, - strand  Genetic Position: Chr8, 23.89 cM
Alliance: Cnot7tm1Tno page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90439
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA lacZ with a nuclear localization signal and a pMC1 neo polyA fragment were inserted in-frame into the exon containing the first methionine via homologous recombination. Northern and western blot analysis confirmed the absence of RNA and protein expression in homozygous mutants. LacZ expression was detected in the seminiferous tubules. (J:90439)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cnot7 Mutation:  28 strains or lines available
References
Original:  J:90439 Nakamura T, et al., Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta. Nat Genet. 2004 May;36(5):528-33
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory