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Npc2tm1Plob
Targeted Allele Detail
Nomenclature
Symbol: Npc2tm1Plob
Name: Niemann-Pick type C2; targeted mutation 1, Peter Lobel and David Sleat
MGI ID: MGI:3044774
Synonyms: NPC2-
Gene: Npc2  Location: Chr12:84754560-84773112 bp, - strand  Genetic Position: Chr12, 39.37 cM
Neurodegenerative changes affecting cerebullar Purkinje cells of Npc1m1N/Npc1m1N, Npc2tm1Plob/Npc2tm1Plob, and double homozygous mice for Npc1m1N and Npc2tm1Plob

Show the 1 image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89617
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (other)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npc2 Mutation:  8 strains or lines available
References
Original:  J:89617 Sleat DE, et al., Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5886-91
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory