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Tcf7l1tm2Efu
Targeted Allele Detail
Nomenclature
Symbol: Tcf7l1tm2Efu
Name: transcription factor 7 like 1 (T cell specific, HMG box); targeted mutation 2, Elaine Fuchs
MGI ID: MGI:3044616
Synonyms: Tcf3-
Gene: Tcf7l1  Location: Chr6:72626371-72789045 bp, - strand  Genetic Position: Chr6, 32.27 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90402
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP flanked 64 bp segment of exon 2 and a neo cassette were inserted via homologous recombination then removed via cre mediated recombination prior to generation of chimeric mice. The resulting allele lacked exon 2 and contained a frameshift and early termination codon. Immunoblot analysis confirmed the absence of protein expression in homozygous embryos (J:90402)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 72 assay results
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf7l1 Mutation:  77 strains or lines available
References
Original:  J:90402 Merrill BJ, et al., Tcf3: a transcriptional regulator of axis induction in the early embryo. Development. 2004 Jan;131(2):263-74
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory