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Transgene Detail
Symbol: Tg(Actb-NOTCH1)2Shn
Name: transgene insertion 2, Jie Shen
MGI ID: MGI:3044584
Synonyms: CALSL-NICD(L)
Transgene: Tg(Actb-NOTCH1)2Shn  Location: unknown  
Strain of Origin:  C57BL/6J
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Actb-NOTCH1)2Shn expresses 1 gene
Mutation detailsThis transgene consists of the chicken Actb followed by a loxP flanked stop, the human NOTCH1 intracellular domain (amino acids 1762-2304) and an SV40 late polyadenylation signal. Cre mediated recombination removes the stop and allows expression of the NOTCH1 gene. Only single site insertions were used to generate mice. This line carries 1 - 2 copies of the transgene and no protein is detectable by western blot analysis after cre mediated recombination. (J:90392)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:90392 Yang X, et al., Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol. 2004 May 1;269(1):81-94
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory