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Tg(ACTB-NOTCH1)1Shn
Transgene Detail
Nomenclature
Symbol: Tg(ACTB-NOTCH1)1Shn
Name: transgene insertion 1, Jie Shen
MGI ID: MGI:3044583
Synonyms: CALSL-NICD
Transgene: Tg(ACTB-NOTCH1)1Shn  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(ACTB-NOTCH1)1Shn expresses 1 gene
 
Mutation detailsThis transgene consists of the chicken beta-actin promoter followed by a loxP flanked stop, the human NOTCH1 intracellular domain (amino acids 1762-2304), and an SV40 late polyadenylation signal. Cre mediated recombination removes the stop and allows expression of the NOTCH1 gene. Only single site insertions were used to generate mice. This line carries 10 - 20 copies of the transgene and protein is detectable by western blot analysis after cre mediated recombination. (J:90392)
Phenotypes
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:90392 Yang X, et al., Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol. 2004 May 1;269(1):81-94
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory