Twist2^tm1(cre)Dor
Targeted Allele Detail

Summary

• Symbol: Twist2^tm1(cre)Dor
• Name: twist basic helix-loop-helix transcription factor 2; targeted mutation 1, David M Ornitz
• MGI ID: MGI:3044412
• Synonyms: Dermo1^cre, Dermo1Cre, Dermo-1^Cre, Dermo1-Cre, Dermo^cre, DM1-Cre, twist-2^-, Twist2^tm1(cre)Eno
• Gene: Twist2 Location: Chr1:91729183-91775750 bp, + strand Genetic Position: Chr1, 46.24 cM
• Alliance: Twist2^tm1(cre)Dor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81485
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Twist2^tm1(cre)Dor expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Twist2 (MGI:104685)

• Mutation details: Exon 1 was replaced with a cre recombinase gene and an FRT-flanked neo cassette. Southern blot analysis confirmed recombination. Cre was expressed in the developing skeleton, specifically in mesenchymal condensations giving rise to both osteoblast and chondrocyte lineages. (J:90391)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Twist2 (mouse) Summary of all recombinase alleles driven by Twist2. Comparative matrix view of recombinase activities Alliance mouse Twist2 gene page

Expression

In Mice Carrying this Mutation:	60 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	22 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Twist2 Mutation: 10 strains or lines available

References

• Original: J:81485 Sosic D, et al., Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Cell. 2003 Jan 24;112(2):169-80
• All: 83 reference(s)