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Nr1i3tm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Nr1i3tm1Dgen
Name: nuclear receptor subfamily 1, group I, member 3; targeted mutation 1, Deltagen
MGI ID: MGI:3044371
Synonyms: CAR -, Nr1i3tm1Sakl
Gene: Nr1i3  Location: Chr1:171213970-171220701 bp, + strand  Genetic Position: Chr1, 79.21 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90553
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsNucleotides 38 to 159 of the open reading frame including the region encoding for the first zinc finger of the DNA binding domain were deleted by homologous recombination. This recombination event introduced a frameshift. (J:90553)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr1i3 Mutation:  11 strains or lines available
References
Original:  J:90553 Maglich JM, et al., Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol Pharmacol. 2002 Sep;62(3):638-46
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory