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Targeted Allele Detail
Symbol: Twsg1tm1Emdr
Name: twisted gastrulation BMP signaling modulator 1; targeted mutation 1, E M De Robertis
MGI ID: MGI:3044357
Synonyms: Tsg-, Twsg1lacZ
Gene: Twsg1  Location: Chr17:65923066-65951187 bp, - strand  Genetic Position: Chr17, 35.26 cM
Germline Transmission:  Earliest citation of germline transmission: J:90398
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsIn-frame insertion of a lacZ reporter into exon 1 at the start codon resulted in the deletion of exon 1, which encodes the first 40 amino acids of the protein, including the entire signal peptide. RT-PCR indicated no transcript present in mutant embryonic cells. (J:90398)
View phenotypes for all genotypes (concatenated display).
In Mice Carrying this Mutation: 33 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Twsg1 Mutation:  12 strains or lines available
Original:  J:90398 Zakin L, et al., Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development. Development. 2004 Jan;131(2):413-24
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory