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Tfectm1Est
Targeted Allele Detail
Nomenclature
Symbol: Tfectm1Est
Name: transcription factor EC; targeted mutation 1, Eirikur Steingrimsson
MGI ID: MGI:3044120
Synonyms: TfecFcr
Gene: Tfec  Location: Chr6:16833373-16898441 bp, - strand  Genetic Position: Chr6, 7.61 cM, cytoband E4-G
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89821
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 5 kb genomic fragment encompassing 2 exons and encoding a portion of the bHLH-Zip domain was replaced with a PGK-neo cassette inserted by homologous recombination. Transcript was undetected by RT-PCR analysis of renal RNA obtained from homozygous mutant mice. (J:89821)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tfec Mutation:  11 strains or lines available
References
Original:  J:89821 Steingrimsson E, et al., Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4477-82
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory