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Drd3tm1Stl
Targeted Allele Detail
Nomenclature
Symbol: Drd3tm1Stl
Name: dopamine receptor D3; targeted mutation 1, Susumu Tonegawa
MGI ID: MGI:3044114
Synonyms: D3-, D3R KO
Gene: Drd3  Location: Chr16:43762221-43822932 bp, + strand  Genetic Position: Chr16, 28.44 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43791
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo cassette replaced exon 1. Southern blot analysis confirmed recombination. Autoradiographic analysis confirmed the absence of Drd3 binding sites in brains of homozygous mice. (J:43791)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Drd3 Mutation:  30 strains or lines available
References
Original:  J:43791 Xu M, et al., Dopamine D3 receptor mutant mice exhibit increased behavioral sensitivity to concurrent stimulation of D1 and D2 receptors. Neuron. 1997 Oct;19(4):837-48
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory