Idd13^C57BL/6
QTL Variant Detail

Summary

• QTL variant: Idd13^C57BL/6
• Name: insulin dependent diabetes susceptibility 13; C57BL/6
• MGI ID: MGI:3044074
• QTL: Idd13 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: C57BL/6

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:20685

The authors describe the derivation of a diabetes resistant mouse strain, NOR/Lt, used in the identification of a new insulin-dependent diabetes susceptibility locus (Idd13) on Chromosome 2. NOR/Lt is a recombinant congenic strain in which portions of the NOD/Lt genome has been replaced by DNA from the C57BL/KsJ strain. Genotypic analysis of the progeny from a (NOD/Lt x NOR/Lt)F2 cross using the Chi square test indicates that Idd13 maps between B2m and Pcna, very near Il1. This location was confirmed by the analysis of congenic strains where Idd13 from the NOR/Lt strain cosegregates with Il1, D2Mit47 and D2Mit48 onto the NOD/Lt background. Together these studies indicate that the order of loci in this region of Chromosome 2 is: B2m, Idd13, Il1, D2Mit47, D2Mit48. Homozygosity for NOR/Lt-derived alleles confer resistance to IDDM at Idd13.

References

• Original: J:85823 Matsuki N, et al., Genetic dissection of V alpha 14J alpha 18 natural T cell number and function in autoimmune-prone mice. J Immunol. 2003 Jun 1;170(11):5429-37
• All: 2 reference(s)