Aldh1a3tm1.1Pcn
Targeted Allele Detail
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Symbol: |
Aldh1a3tm1.1Pcn |
Name: |
aldehyde dehydrogenase family 1, subfamily A3; targeted mutation 1.1, Pierre Chambon |
MGI ID: |
MGI:3043947 |
Synonyms: |
Aldh1a3KO, Aldh1a3L- |
Gene: |
Aldh1a3 Location: Chr7:66040640-66077225 bp, - strand Genetic Position: Chr7, 35.73 cM, cytoband C
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Alliance: |
Aldh1a3tm1.1Pcn page
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Aldh1a3tm1.1Pcn/Aldh1a3tm1.1Pcn mice develop ocular and nasal defects
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:90261
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129/Sv
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: This allele was derived from Aldh1a3tm1Pcn by crossing carriers of that allele with CMV-Cre expressing transgenics which results in the excision of exons 8 and 9 and thus the loss of the catalytic site in the protein product.
(J:90261)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Aldh1a3 Mutation: |
25 strains or lines available
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Original: |
J:90261 Dupe V, et al., A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14036-41 |
All: |
7 reference(s) |
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