Mlxipl^tm1Kuy
Targeted Allele Detail

Summary

• Symbol: Mlxipl^tm1Kuy
• Name: MLX interacting protein-like; targeted mutation 1, Kosaku Uyeda
• MGI ID: MGI:3043871
• Synonyms: ChREBP-
• Gene: Mlxipl Location: Chr5:135118744-135167236 bp, + strand Genetic Position: Chr5, 75.0 cM
• Alliance: Mlxipl^tm1Kuy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89865
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The genomic region spanning exons 12 - 14 was replaced with a neo cassette via homologous recombination. Real-time RT-PCR confirmed the absence of mRNA expression in homozygous mice. (J:89865)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mlxipl Mutation: 54 strains or lines available

References

• Original: J:89865 Iizuka K, et al., Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci U S A. 2004 Jun 11;101(19):7281-6
• All: 23 reference(s)