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Targeted Allele Detail
Symbol: Slc14a2tm1Raf
Name: solute carrier family 14 (urea transporter), member 2; targeted mutation 1, Robert A Fenton
MGI ID: MGI:3043851
Synonyms: UT-A1/3 -
Gene: Slc14a2  Location: Chr18:78146940-78209094 bp, - strand  Genetic Position: Chr18, 52.53 cM
Germline Transmission:  Earliest citation of germline transmission: J:89834
Parent Cell Line:  CMTI-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 10 was replaced with a pgk-neo cassette via homologous recombination. This selectively deleted two of the isoforms (UT-A1 and UT-A3). Immunoblot analysis confirmed the absence of the UT-A1 and UT-A3 proteins and the presence of the UT-A2 protein. A fourth testis specific isoform, UT-A5, also contains exon 10 and is predicted to be deleted. (J:89834)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc14a2 Mutation:  34 strains or lines available
Original:  J:89834 Fenton RA, et al., Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting duct. Proc Natl Acad Sci U S A. 2004 May 11;101(19):7469-74
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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