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Tg(Ins1-Cat,Tyr)25Pne
Transgene Detail
Nomenclature
Symbol: Tg(Ins1-Cat,Tyr)25Pne
Name: transgene insertion 25, Paul N Epstein
MGI ID: MGI:3043843
Synonyms: RipCat
Transgene: Tg(Ins1-Cat,Tyr)25Pne  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ins1-Cat,Tyr)25Pne expresses 2 genes
 
Mutation detailsThe symbol represents a double transgene. In one transgene, a rat insulin I promoter drives the expression of a rat catalase cDNA. Northern blot analysis and immunohistochemistry detected expression of this transgene in pancreatic beta cells. A second transgene that expresses tyrosinase under control of the tyrosinase promoter was coinjected with the first transgene, and apparently cosegregated. (J:59725)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:59725 Xu B, et al., Overexpression of catalase provides partial protection to transgenic mouse beta cells. Free Radic Biol Med. 1999 Oct;27(7-8):830-7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory