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Glra3tm1.1Umu
Targeted Allele Detail
Nomenclature
Symbol: Glra3tm1.1Umu
Name: glycine receptor, alpha 3 subunit; targeted mutation 1.1, Ulrike Muller
MGI ID: MGI:3043776
Synonyms: GlyR alpha3-
Gene: Glra3  Location: Chr8:55940460-56130070 bp, + strand  Genetic Position: Chr8, 29.69 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89981
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe floxed fragment containing exon 7 and a neo cassette were excised via cre mediated recombination. Immunostaining confirmed the absence of protein in the dorsal horn of the brain in homozygotes. (J:89981)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Glra3 Mutation:  28 strains or lines available
References
Original:  J:89981 Harvey RJ, et al., GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization. Science. 2004 May 7;304(5672):884-7
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory