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FblGt(pGT1-3)1Jca
Gene trapped Allele Detail
Nomenclature
Symbol: FblGt(pGT1-3)1Jca
Name: fibrillarin; gene trap 1, Javier F Caceres
MGI ID: MGI:3043754
Synonyms: Fibrillarin-
Gene: Fbl  Location: Chr7:27869135-27878694 bp, + strand  Genetic Position: Chr7, 16.67 cM, cytoband A1
Mutation
origin
Mutant Cell Line:  ES403
Germline Transmission:  Earliest citation of germline transmission: J:89938
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector Type: gene trap
 
Mutation detailsThe endogenous locus was disrupted by insertion into intron 4 of the pGT1,-2, or-3 retroviral gene trap vector containing a splice acceptor site, beta-geo, and an SV40 poly-A signal. A fusion protein consisting of the N-terminal 132 amino acids of the Fbl protein fused to lacZ is expressed from the mutated locus. (J:71817, J:89938)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fbl Mutation:  17 strains or lines available
References
Original:  J:89938 Newton K, et al., Fibrillarin is essential for early development and required for accumulation of an intron-encoded small nucleolar RNA in the mouse. Mol Cell Biol. 2003 Dec;23(23):8519-27
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory