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Igf2bp1Gt(OST33739)Lex
Gene trapped Allele Detail
Nomenclature
Symbol: Igf2bp1Gt(OST33739)Lex
Name: insulin-like growth factor 2 mRNA binding protein 1; gene trap OST33739, Lexicon Genetics
MGI ID: MGI:3043746
Synonyms: Igf2bp1Gt(Betageo)1Fcn, Imp1-, Imp1Beta-geo, Zbp1-
Gene: Igf2bp1  Location: Chr11:95957163-96005940 bp, - strand  Genetic Position: Chr11, 59.08 cM
Mutation
origin
Mutant Cell Line:  OST33739
Germline Transmission:  Earliest citation of germline transmission: J:89882
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector
 
Mutation detailsA retroviral gene trap vector, containing a 5' LTR followed by a splice acceptor, beta-geo, PGK-puro, stop codons, a splice donor, and a 3' LTR, was inserted into intron 2. Insertion of the gene trap vector led to deletion of the second RNA recognition motif and the four K-homology modules, known to be essential for RNA binding, cytoplasmic granule formation, and subcytoplasmic localization. Normal transcript was undetected by RT-PCR analysis of homozygous mutant embryos. (J:89882)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Igf2bp1 Mutation:  96 strains or lines available
Notes
See also, data as provided by Lexicon Genetics, Inc.
References
Original:  J:89882 Hansen TV, et al., Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice. Mol Cell Biol. 2004 May;24(10):4448-64
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory