Apoa2^b
Allele Detail

Summary

• Symbol: Apoa2^b
• Name: apolipoprotein A-II; b variant
• MGI ID: MGI:3043622
• Gene: Apoa2 Location: Chr1:171052623-171053948 bp, + strand Genetic Position: Chr1, 79.22 cM
• Alliance: Apoa2^b page

Mutation origin

• Strain of Origin: various

Mutation description

• Allele Type: Not Applicable
• Mutation: Not Applicable
• Mutation details: This allele encodes a proline at position 5, a glutamic acid at position 20, a valine at positions 26, 38 and 61. This allele is found on BALB/C, CBA/N, C3H/He, DDD, NZB/N, ICR:slc, SAMP6, and SAMR1 backgrounds, also found in 129, FVB, KK, LP, MRL, NON, NZW, RF. (J:11543, J:92800)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apoa2 Mutation: 16 strains or lines available

Notes

This allele shows association with increased plasma cholesterol levels. Plasma HDL concentrations are significantly higher in strains carrying this allele than in other strains J:92800.

References

• Original: J:11543 Higuchi K, et al., Polymorphism of apolipoprotein A-II (apoA-II) among inbred strains of mice. Relationship between the molecular type of apoA-II and mouse senile amyloidosis. Biochem J. 1991 Oct 15;279(Pt 2):427-33
• All: 4 reference(s)