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Targeted Allele Detail
Symbol: Ercc5tm3Shm
Name: excision repair cross-complementing rodent repair deficiency, complementation group 5; targeted mutation 3, Tadahiro Shiomi
MGI ID: MGI:3043589
Synonyms: XpgD811stop
Gene: Ercc5  Location: Chr1:44147744-44181260 bp, + strand  Genetic Position: Chr1, 23.55 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:89911
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA stop codon was introduced at amino acid 811 and a loxP flanked PGK-neo cassette added via homologous recombination. This C-terminal truncation removed the last 360 amino acids. Northern blot analysis confirmed the presence of mRNA of normal size and amount. (J:89911)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ercc5 Mutation:  37 strains or lines available
Original:  J:89911 Shiomi N, et al., Identification of the XPG region that causes the onset of Cockayne syndrome by using Xpg mutant mice generated by the cDNA-mediated knock-in method. Mol Cell Biol. 2004 May;24(9):3712-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory