Neurl2^tm1Adz
Targeted Allele Detail

Summary

• Symbol: Neurl2^tm1Adz
• Name: neuralized E3 ubiquitin protein ligase 2; targeted mutation 1, Alessandro dAzzo
• MGI ID: MGI:3043523
• Synonyms: Ozz-
• Gene: Neurl2 Location: Chr2:164672652-164675376 bp, - strand Genetic Position: Chr2, 85.27 cM
• Alliance: Neurl2^tm1Adz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90054
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A lacZ-pGK-Neo cassette was inserted into exon 1 via homologous recombination. Heart and skeletal muscle were shown to lack mRNA and protein expression in homozygotes. Ppgb mRNA and activity were also reduced in homozygotes but only to the level seen in Ppgb^tm1Adz heterozygotes which do not show any obvious abnormalities. (J:90054)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Neurl2 Mutation: 14 strains or lines available

References

• Original: J:90054 Nastasi T, et al., Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis. Dev Cell. 2004 Feb;6(2):269-82
• All: 2 reference(s)