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Ptpn22tm1Achn
Targeted Allele Detail
Nomenclature
Symbol: Ptpn22tm1Achn
Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid); targeted mutation 1, Andrew C Chan
MGI ID: MGI:3043469
Synonyms: pep-, pep(E8)-
Gene: Ptpn22  Location: Chr3:103859795-103912247 bp, + strand  Genetic Position: Chr3, 45.52 cM, cytoband F3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90029
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 8, encoding the phosphatase domain, was replaced with a neo cassette via homologous recombination. Immunoblot analysis confirmed the absence of wild-type or truncated protein in thymocytes and splenocytes from homozygotes. (J:90029)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptpn22 Mutation:  5 strains or lines available
References
Original:  J:90029 Hasegawa K, et al., PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells. Science. 2004 Jan 30;303(5658):685-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory