Uaca^tm1Kiy
Targeted Allele Detail

Summary

• Symbol: Uaca^tm1Kiy
• Name: uveal autoantigen with coiled-coil domains and ankyrin repeats; targeted mutation 1, Kiyoshi Fukui
• MGI ID: MGI:3043446
• Synonyms: Nucling-
• Gene: Uaca Location: Chr9:60701824-60787652 bp, + strand Genetic Position: Chr9, 32.93 cM, cytoband C
• Alliance: Uaca^tm1Kiy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89918
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neo was inserted into the exon encoding the LZ motif. Northern blot and Western blot confirmed gene disruption by lack of transcript in heart and skeletal muscle and protein in MEFs, respectively. (J:93333)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Uaca Mutation: 71 strains or lines available

References

• Original: J:89918 Liu L, et al., Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signalling. Biochem J. 2004 May 15;380(Pt 1):31-41
• All: 5 reference(s)