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Targeted Allele Detail
Symbol: Uacatm1Kiy
Name: uveal autoantigen with coiled-coil domains and ankyrin repeats; targeted mutation 1, Kiyoshi Fukui
MGI ID: MGI:3043446
Synonyms: Nucling-
Gene: Uaca  Location: Chr9:60794548-60880370 bp, + strand  Genetic Position: Chr9, 32.93 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:89918
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA PGK-neo was inserted into the exon encoding the LZ motif. Northern blot and Western blot confirmed gene disruption by lack of transcript in heart and skeletal muscle and protein in MEFs, respectively. (J:93333)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Uaca Mutation:  5 strains or lines available
Original:  J:89918 Liu L, et al., Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signalling. Biochem J. 2004 May 15;380(Pt 1):31-41
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory