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Trp53tm1Elee
Targeted Allele Detail
Nomenclature
Symbol: Trp53tm1Elee
Name: transformation related protein 53; targeted mutation 1, Eva YHP Lee
MGI ID: MGI:3043426
Synonyms: p53f5&6, p53flox, p53fp, p53koflox
Gene: Trp53  Location: Chr11:69580359-69591873 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90247
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 5 and 6 were flanked by single loxP sites in introns 4 and 6. Recombination of these loxP sites will result in the deletion of codons 123 through 221, which encode part of the DNA-binding domain. (J:90247)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  133 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Glioblastoma Multiforme (J:149662)

References
Original:  J:90247 Lin SC, et al., Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis. Cancer Res. 2004 May 15;64(10):3525-32
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory