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Tg(Camk2a-MME)3Selk
Transgene Detail
Nomenclature
Symbol: Tg(Camk2a-MME)3Selk
Name: transgene insertion 3, Dennis J Selkoe
MGI ID: MGI:3043425
Synonyms: 8xNEP
Transgene: Tg(Camk2a-MME)3Selk  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Homozygous mutant mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.

Transgenic mice have poor reproductive performance.

In conjunction with Tg(PDGFB-APPSwInd)20Lms, transgenic mice do not develop amyloid beta plaques.

References
Original:  J:87150 Leissring MA, et al., Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron. 2003 Dec 18;40(6):1087-93
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory