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Transgene Detail
Symbol: Tg(Camk2a-MME)3Selk
Name: transgene insertion 3, Dennis J Selkoe
MGI ID: MGI:3043425
Synonyms: 8xNEP
Transgene: Tg(Camk2a-MME)3Selk  Location: unknown  
Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Camk2a-MME)3Selk expresses 1 gene
Mutation detailsTransgenic mice express human membrane metallo-endopeptidase (MME) under the direction of the mouse calcium/calmodulin-dependent protein kinase II alpha (Camk2a) promoter. Transgene expression is approximately 8 fold relative to wildtype controls, as detected by quantitative Western blot analysis and protease activity assay. The levels of soluble alpha beta-amyloid X-40 and soluble alpha beta-amyloid X-42 are reduced in 2 to 3 month old transgenic mice. (J:87150)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Homozygous mutant mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.

Transgenic mice have poor reproductive performance.

In conjunction with Tg(PDGFB-APPSwInd)20Lms, transgenic mice do not develop amyloid beta plaques.

Original:  J:87150 Leissring MA, et al., Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron. 2003 Dec 18;40(6):1087-93
All:  2 reference(s)

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MGI 6.03
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