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Scn1btm1Isom
Targeted Allele Detail
Nomenclature
Symbol: Scn1btm1Isom
Name: sodium channel, voltage-gated, type I, beta; targeted mutation 1, Lori L Isom
MGI ID: MGI:3043422
Synonyms: Beta1 (-)
Gene: Scn1b  Location: Chr7:31116524-31127003 bp, - strand  Genetic Position: Chr7, 19.3 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90136
Parent Cell Line:  Pat5 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 as well as the 73 bp of intron 3 that are required for the expression of the Beta1A embryonic splice variant were replaced by a neomycin cassette inserted by homologous recombination. Transcript was undetected in homozygous mutant mice by Northern blot analysis of brain RNA. (J:90136)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn1b Mutation:  2 strains or lines available
References
Original:  J:90136 Chen C, et al., Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci. 2004 Apr 21;24(16):4030-42
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory