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Scn8atm1Mm
Targeted Allele Detail
Summary
Symbol: Scn8atm1Mm
Name: sodium channel, voltage-gated, type VIII, alpha; targeted mutation 1, Miriam Meisler
MGI ID: MGI:3043395
Synonyms: Scn8aflox
Gene: Scn8a  Location: Chr15:100767739-100943819 bp, + strand  Genetic Position: Chr15, 56.39 cM, cytoband F1
Alliance: Scn8atm1Mm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91696
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites have been inserted 107 bp upstream and 134 bp downstream flanking exon 1, the first coding exon. An frt flanked neomycin resistance cassette was inserted downstream of of exon 1 as well. Mice were bred to transgenic mice expressing Flp recombinase to excise the neomycin cassette in the germ line. The resulting mice containing a floxed exon 1 were bred to homozygosity. Normal protein levels were detected by Western blot analysis. (J:91696)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn8a Mutation:  99 strains or lines available
References
Original:  J:91696 Levin SI, et al., Floxed allele for conditional inactivation of the voltage-gated sodium channel Scn8a (Na(v)1.6). Genesis. 2004 Aug;39(4):234-9
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory