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Targeted Allele Detail
Symbol: Cdk11btm1Vjk
Name: cyclin-dependent kinase 11B; targeted mutation 1, Vincent J Kidd
MGI ID: MGI:3043373
Synonyms: cdc2l-, CDK11p110/p58-
Gene: Cdk11b  Location: Chr4:155624854-155649938 bp, + strand  Genetic Position: Chr4, 86.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:89908
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 10.3 kb genomic segment including exons 3 - 5 of the locus were replaced with a TK-neo cassette via homologous recombination. Immunofluorescence microscopy analysis confirmed the absence of both the p58 and p110 isoforms. (J:89908)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdk11b Mutation:  30 strains or lines available
Original:  J:89908 Li T, et al., Failure to proliferate and mitotic arrest of CDK11(p110/p58)-null mutant mice at the blastocyst stage of embryonic cell development. Mol Cell Biol. 2004 Apr;24(8):3188-97
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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