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Mapttm1(Mecp2)Jae
Targeted Allele Detail
Nomenclature
Symbol: Mapttm1(Mecp2)Jae
Name: microtubule-associated protein tau; targeted mutation 1, Rudolf Jaenisch
MGI ID: MGI:3043293
Synonyms: Tau-Mecp2 ki
Gene: Mapt  Location: Chr11:104231390-104332090 bp, + strand  Genetic Position: Chr11, 67.79 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89593
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutation:    Insertion
 
Mapttm1(Mecp2)Jae expresses 1 gene
 
Mutation detailsThe mouse Mecp2 coding sequence, a modified Kozak sequence and a neo-cassette were placed in-frame into exon 1 of Mapt via homologous combination. The resulting fusion protein contained the first 31 amino acids of Mapt fused to Mecp2 and was highly expressed in the brain (in post-mitotic neurons), lung, and kidney. (J:89593)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapt Mutation:  393 strains or lines available
References
Original:  J:89593 Luikenhuis S, et al., Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6033-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory